Improving Treatment of Ischemic Organ Injury through Innovative Translational Research

Our lab, led by an anesthesiologist and transplant surgeon, is uniquely positioned to investigate issues relevant to ischemic organ injury, which occurs when the blood supply to an organ is either partially or totally cut off. Our goal is to translate these findings through clinical trials with a view towards rapidly improving medical and surgical techniques. Our findings in the lab inform our work in the clinic and our clinical trials provide us with data that informs future research in the lab. All of these will result in improved outcomes for patients.

As two examples of this kind of research, we have found that mild hypothermia is extremely beneficial at ameliorating ischemia-reperfusion injury of the liver, even in fatty livers which are exceedingly susceptible to ischemic injury. We have also found that high blood sugar is can greatly exacerbate ischemic injury of the kidney. Both of these findings may have an immediate impact on how we deal with ischemia of the liver or of the kidney in a variety of settings, including vascular, urologic, oncologic and transplant surgery.

Recent Publications

Parekh J, Roll GR, Feng S, Niemann CU, Hirose R
Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.
Clinical transplantation, 274: E424-30.  Epub 2013 Jun 30.
Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA
Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.
Critical care medicine, Jun-01-2008; 366: 1846-54.
Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU
Remote renal injury following partial hepatic ischemia/reperfusion injury in rats.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, Mar-01-2008; 123: 490-5.  Epub 2007 Aug 14.
Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU
Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.
Anesthesiology, Mar-01-2008; 1083: 402-14.
Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU
Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model.
Surgery, Feb-01-2008; 1432: 243-51.  Epub 2007 Dec 27.
Niemann CU, Serkova NJ
Biochemical mechanisms of nephrotoxicity: application for metabolomics.
Expert opinion on drug metabolism & toxicology, Aug-01-2007; 34: 527-44.
Fuller TF, Rose F, Singleton KD, Linde Y, Hoff U, Freise CE, Dragun D, Niemann CU
Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury.
The Journal of surgical research, Jun-01-2007; 1401: 77-83.  Epub 2007 Feb 9.
Serkova NJ, Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell MS
Early detection of graft failure using the blood metabolic profile of a liver recipient.
Transplantation, Feb-27-2007; 834: 517-21.
Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP
Central venous pressure monitoring during living right donor hepatectomy.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Feb-01-2007; 132: 266-71.
Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU
Ischemia-reperfusion injury is more severe in older versus young rat livers.
The Journal of surgical research, Jan-01-2007; 1371: 96-102.  Epub 2006 Oct 24.
Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ
Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.
Surgery, Sep-01-2006; 1403: 404-12.  Epub 2006 Jul 28.
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