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Improving Treatment of Ischemic Organ Injury through Innovative Translational Research

Our lab, led by an anesthesiologist and transplant surgeon, is uniquely positioned to investigate issues relevant to ischemic organ injury, which occurs when the blood supply to an organ is either partially or totally cut off. Our goal is to translate these findings through clinical trials with a view towards rapidly improving medical and surgical techniques. Our findings in the lab inform our work in the clinic and our clinical trials provide us with data that informs future research in the lab. All of these will result in improved outcomes for patients.

As two examples of this kind of research, we have found that mild hypothermia is extremely beneficial at ameliorating ischemia-reperfusion injury of the liver, even in fatty livers which are exceedingly susceptible to ischemic injury. We have also found that high blood sugar is can greatly exacerbate ischemic injury of the kidney. Both of these findings may have an immediate impact on how we deal with ischemia of the liver or of the kidney in a variety of settings, including vascular, urologic, oncologic and transplant surgery.

Recent Publications

Kotloff RM, Blosser S, Fulda GJ, Malinoski D, Ahya VN, Angel L, Byrnes MC, DeVita MA, Grissom TE, Halpern SD, Nakagawa TA, Stock PG, Sudan DL, Wood KE, Anillo SJ, Bleck TP, Eidbo EE, Fowler RA, Glazier AK, Gries C, Hasz R, Herr D, Khan A, Landsberg D, Lebovitz DJ, Levine DJ, Mathur M, Naik P, Niemann CU, Nunley DR, O'Connor KJ, Pelletier SJ, Rahman O, Ranjan D, Salim A, Sawyer RG, Shafer T, Sonneti D, Spiro P, Valapour M, Vikraman-Sushama D, Whelan TP, Whelan TP
Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement.
Critical care medicine, Jun-01-2015; 436: 1291-325.
Patel MS, Niemann CU, Sally MB, De La Cruz S, Zatarain J, Ewing T, Crutchfield M, Enestvedt CK, Malinoski DJ
The Impact of Hydroxyethyl Starch Use in Deceased Organ Donors on the Development of Delayed Graft Function in Kidney Transplant Recipients: A Propensity-Adjusted Analysis.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Apr-22-2015; [Epub ahead of print].
Parekh J, Roll GR, Feng S, Niemann CU, Hirose R
Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.
Clinical transplantation, 274: E424-30.  Epub 2013 Jun 30.
Everson GT, Hoefs JC, Niemann CU, Olthoff KM, Dupuis R, Lauriski S, Herman A, Milne N, Gillespie BW, Goodrich NP, Everhart JE
Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Mar-01-2013; 193: 292-304.
Mone T, Heldens J, Niemann CU
Deceased organ donor research: the last research frontier?.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Feb-01-2013; 192: 118-21.
Wray C, Scovotti JC, Tobis J, Niemann CU, Planinsic R, Walia A, Findlay J, Wagener G, Cywinski JB, Markovic D, Hughes C, Humar A, Olmos A, Sierra R, Busuttil R, Steadman RH
Liver transplantation outcome in patients with angiographically proven coronary artery disease: a multi-institutional study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Jan-01-2013; 131: 184-91.  Epub 2012 Nov 5.
Behrends M, Niemann CU, Larson MD
Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series.
Resuscitation, Oct-01-2012; 8310: 1223-8.  Epub 2012 May 30.
Rando K, Niemann CU, Taura P, Klinck J
Optimizing cost-effectiveness in perioperative care for liver transplantation: a model for low- to medium-income countries.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Nov-01-2011; 1711: 1247-78.
Liu LL, Niemann CU
Intraoperative management of liver transplant patients.
Transplantation reviews (Orlando, Fla.), Jul-01-2011; 253: 124-9.  Epub 2011 Apr 21.
Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU
Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Jun-01-2011; 266: 1813-20.  Epub 2010 Nov 10.
Parekh J, Niemann CU, Dang K, Hirose R
Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study.
Journal of transplantation, 2011: 652458.
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